The Comparative dissolution study in different pH conditions of Bilastine Tablet

Abstract

The dissolution study is designed for the determination of the drug release profile from a solid dosage form in different time interval. The purpose of the study is to determine the difference of two commercially available bilastine tablet in Bangladeshi local market. Three different types of buffer medium are used that pH are 1.2, 4.5 & 6.8. The HPLC characteristics are column kromasil C₁₈, 150 mm X 4.6 mm, 5µm with a mobile phase is constituted with buffer: acetonitrile in the ratio of 6.5:3.5. The flow rate was 1.0 mL/minute; detection was carried out by PDA detector at 207nm in 25°C. The difference factor f₁ and similarity factor f₂ of type A and B category bilastine tablet at pH 1.2 medium are satisfied by the USP guideline and that are respectively 1.01 and 83.27. But in other conditions pH 4.6 and 6.8 not same. These result show that the dissolution profile of B category tablet is not suitable formulation further in vivo test is require for the justification the plasma profile level at different time interval.